Cardiology | Antiarrhythmic Drug Guide | Class III | Sotalol


IV Dose
Oral dose Adults: 80 mg B.I.D. to start, adjusting upwards every 2-3 days to 160 mg B.I.D. Maximum 640 mg daily in life-threatening arrhythmias. Children: 2-8 mg/kg/day divided B.I.D.
Levels Unknown
Kinetics Mean elimination half-life 12 hours. Excreted in urine
Cautions Class II/III actions, so similar to other beta-blockers. Dose, QTc interval and incidence of Torsades are related: QTc should be followed. In particular, maintain normal potassium and magnesium levels, as Torsades is much more common with hypokalemia and/or hypomagnesemia.
Interactions No effect on digoxin. Do not use with class !a agents,as QTc will be further prolonged. As with other beta blockers, will further decrease cardiac function is used with calcium channel blockers
Preparations Betapace scored tablets 80, 160, 240 mg
FDA approval in children no

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